Developing rapid growing Bacillus subtilis for improved biochemical and recombinant protein production
نویسندگان
چکیده
منابع مشابه
Bacillus subtilis as a Host for Recombinant Hemagglutinin Production of the Influenza A (H5N1) Virus
Abstract Background and Aims: Influenza A(H5N1) viruses circulating in animals might evolve and acquire the ability to spread from human to human and thus start a pandemic. Hemagglutinin (HA) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. Recent studies have shown that...
متن کاملProduction of recombinant proteins in Bacillus subtilis.
Project aims 1. Feasibility studies of Bacillus subtilis as an expression host for the production of therapeutically important proteins through high cell density fermentations. 2. Studies on intein mediated purification of therapeutically important proteins expressed in Bacillus subtilis. 3. Case studies with a few proteins of research/commercial relevance including malaria proteins that are li...
متن کاملEnhanced Recombinant Protein Productivity by Genome Reduction in Bacillus subtilis
The emerging field of synthetic genomics is expected to facilitate the generation of microorganisms with the potential to achieve a sustainable society. One approach towards this goal is the reduction of microbial genomes by rationally designed deletions to create simplified cells with predictable behavior that act as a platform to build in various genetic systems for specific purposes. We repo...
متن کاملOptimization of extracellular production of recombinant human bone morphogenetic protein-7 (rhBMP-7) with Bacillus subtilis.
Extracellular production of recombinant human bone morphogenetic protein-7 (rhBMP-7) was carried out through the fermentation of Bacillus subtilis. Three significant fermentation conditions and medium components were selected and optimized to enhance the rhBMP-7 production by using the response surface methodology (RSM). The optimum values of the three variables for the maximum extracellular pr...
متن کاملbacillus subtilis as a host for recombinant hemagglutinin production of the influenza a (h5n1) virus
abstract background and aims: influenza a(h5n1) viruses circulating in animals might evolve and acquire the ability to spread from human to human and thus start a pandemic. hemagglutinin (ha) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. recent studies have shown that glycosylation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Metabolic Engineering Communications
سال: 2020
ISSN: 2214-0301
DOI: 10.1016/j.mec.2020.e00141